Update on Guillain-Barre Syndrome-Like Conditions in Animals
نویسنده
چکیده
Disease conditions, including Coonhound paralysis, acute canine polyradiculoneuropathy (ACP), and cauda equina neuritis do occur in animals naturally from time to time. The experimental induction of paralysis in chickens with certain strains of Campylobacter jejuni, and the recent observation of Toxoplasma-induced ACP raise the possibility that peripheral nerve disease via immunologic mechanisms, induced by microorganisms, may occur in animals naturally. Experimental studies have indicated that antigens responsible for production of cross-reacting antibodies that cause neurological injury may be present in unrelated bacterial pathogens such as C. jejuni and Brucella melitensis. Further studies are required to determine if antibodies against C. jejuni can damage human neural cells including oligodnendroglial cells, the cell type responsible for myelin production in the central nervous system.
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تاریخ انتشار 2011